By Sam Maddox
The Barres Lab is known for studying glial cells and how they interact with other cells in the nervous system. Dr. Barres speculates on potential collaborations with the other Reeve Consortium labs:
Edgerton Lab: "This group is looking at the circuitry of the spinal cord and how, when stimulated, it is able to boost functionality. There is some evidence that spinal cord cells get signals from glial cells. If so, we might be able to understand this, and to help stimulate the spinal cord cells pharmacologically, without need for implanted stimulators."
Fawcett Lab: "This lab studies chondroitinase, which appears to promote axon growth and which is related to glial cells. They are also looking at other molecular signals to understand how axons are switched on in development. My lab can help understand some of the basic biology of these signaling processes."
Schwab Lab: "The lab has recently done some very interesting work with axon sprouting. Reactive glial cells are involved; we are very focused on this area at this time."
Pfaff Lab: "This group is focused on motor neurons, the cells that transmit signals from the brain or spinal cord to muscles. Our lab shares an interest in axon guidance and how these circuits are formed, and how they might be reformed after injury."
Mendell Lab: "This lab is expert in testing the behavioral and functional effects of experimental therapies with electrophysiology. We hope our work, as it evolves, can benefit by these sorts of measurements. We look forward to collaborations with all the Consortium labs.
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