Overview of Recent Publications
about the NRN and NACTN
"Yes, we can make a difference, we can get something done, because obviously what was so controversial ten years ago, the role of rehabilitation, that's no longer an issue -- scientists, researchers all over the world now understand...
the idea is finally catching hold that rehab on its own can help people recover..."
- Christopher Reeve, 2004, in his last public speech
Historic findings featured in the Archives of Physical Medicine & Rehabilitation demonstrate that the Christopher & Dana Reeve Foundation NeuroRecovery Network's (NRN) locomotor training works and brings about significant improvements in function and health outcomes for individuals living with spinal cord injury. The NRN's trailblazing therapy is achieving scientific validation that is crucial in and of itself as well as in furthering legislation and funding in support of rehabilitation and research.
Meanwhile, the important role that the Reeve Foundation North American Clinical Trials Network (NACTN) plays in bringing promising therapies to clinical trial is the focus of an entire supplement to the Journal of Neurosurgery: Spine. NACTN's collaborative multicenter network has collected vital data through a patient registry and has provided an essential infrastructure that informs translational research decisions. NACTN investigators recently completed a Phase I safety trial of the drug Riluzole; they are now planning a Phase II randomized efficacy study.
11 Studies Reveal Effectiveness of the NeuroRecovery Network
Using rigorous evaluation and analysis, data from 296 spinal cord injury (SCI) patients at seven centers across the country suggest that locomotor training can be part of the reparative process after spinal cord injury and promotes improvements in the neuromuscular system. READ MORE.
What the NRN Studies Mean: Improved health and function
Intensive, activity-based rehabilitation therapy can lead to significant functional improvements in patients with spinal cord injuries. New research, based on studies from the Christopher & Dana Reeve Foundation NeuroRecovery Network (NRN), shows that recovery of walking and balance can occur even years after injury in people with incomplete spinal cord injury who participate in locomotor training. READ MORE.
Therapies for SCI: On the cutting edge of clinical translation
Spinal cord injury research has matured to the extent that clinical trials are being held, or planned, for a number of very promising therapeutic approaches. This is a new era for the field, moving from research to application. But any form of this so-called translational research requires a coordinated approach to the process, from preclinical data assessment and trial protocols to actual treatment and outcome measures. READ MORE.