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Breakthrough experimental epidural stimulation for spinal cord injury

Epidural stimulation results in "Unprecedented Breakthrough" for paralysis community
Four young men who have been paralyzed for years achieved groundbreaking progress – moving their legs – as a result of epidural electrical stimulation of the spinal cord. New research published in the medical journal Brain documents the effectiveness of epidural stimulation as a therapy option for chronic motor complete spinal cord injuries. The study was funded in part by the Christopher & Dana Reeve Foundation.

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Continue Christopher Reeve's LegacyPhoto by Timothy Greenfield-Sanders

The Research

Oxford Journals | Medicine | Brain

- Review the paper and observations published in the medical journal Brain
- Overview of the study and key insights from the researchers
- Meet the scientists who are pioneering epidural stimulation and SCI research
- Learn more about the study participants in Progress in Research
- Oxford University Press Q/A
- Voluntary movement shown in complete paralysis

Participant Biographies

Participants Bios

Four remarkable men with injuries ranging from C7-T5 agreed to participate in the epidural stimulation study and the results have transformed their lives. Introducing the "fourth power" -- the participants who have moved us closer to delivering on the Reeve Foundation mission. LEARN MORE.

Press Coverage

See how the world reacted to the transformational research published in Brain.
- Links to worldwide media coverage
- Follow us on Twitter @ReeveFoundation
- Follow #FourthPower
- Find us on Facebook


The National Institute of Biomedical Imaging and Bioengineering is supporting Dr. V. Reggie Edgerton (UCLA) and his collaborators at Caltech to develop a new electrode array for use in rats. Their goal is to assess what effect a more sophisticated technology will have on locomotion. Their findings will be translated to the clinic, where investigators hope to optimize recovery of health outcomes and locomotion in patients. Find out more from the NIBIB.

A Word From Reeve President/CEO

Peter Wilderotter

Peter Wilderotter shares his insights about the impact of epidural stimulation as a therapy intervention for individuals living with a spinal cord injury. Additionally, he explains how innovative and pioneering research fuels the Reeve Foundation forward: "There is more work to be done, but we are dedicated to discover cures in the here and now." READ MORE.

What is Epidural Stimulation

Epidural Stimulation

Review top questions asked about epidural stimulation to better understand the study results as reported by the research team, as well as other important insights and observations noted in the Brain paper.
What is epidural stimulation?
Is it possible for me to qualify as a subject for this research?

Media Kit

Read our blog on worldwide SCI research

Spinal Injury Research News

Stay informed about the latest discoveries and news in SCI research. READ OUR BLOG.

Support cutting-edge research

Support cutting-edge research

The Reeve Foundation mission is to advance care and discover cures for paralysis, which is why the organization invests in innovative and pioneering research. Support Reeve Foundation research to help more people like Rob, Kent, Andrew and Dustin improve function, health and quality of life. Together we achieve more for the millions of people living with paralysis. DONATE NOW!

Thank You to Our Partners

University of Louisville's Kentucky Spinal Cord Injury Research Center UCLA Newsroom

Epidural Stimulation Videos