Leukodystrophies
Overview of leukodystrophies
Leukodystrophies are progressive, hereditary disorders that affect the brain, spinal cord, and peripheral nerves. Specific leukodystrophies include:
- Metachromatic leukodystrophy
- Krabbe disease
- Adrenoleukodystrophy
- Canavan disease
- Alexander disease
- Zellweger syndrome
- Refsum disease
- Cerebrotendinous xanthomatosis
- Pelizaeus-Merzbacher disease can also lead to paralysis
Adrenoleukodystrophy (ALD) affected the young boy Lorenzo Odone, whose story is told in the 1993 film "Lorenzo's Oil." In this disease, the myelin sheath on nerve fibers in the brain is lost and the adrenal gland degenerates, leading to progressive neurological disability.
For more information, see The Myelin Project, established in 1989 by Augusto and Michaela Odone with the goal of accelerating research on myelin repair.
Resource
If you are looking for more information on leukodystrophies or have a specific question, our information specialists are available business weekdays, Monday through Friday, toll-free at 800-539-7309 from 9am to 8pm ET.
Additionally, the United Leukodystrophy Foundation (ULF) raises funds, offers resources and clinical detail on the leukodystrophies.
Related pages
- Acute flaccid myelitis
- Amyotrophic lateral sclerosis
- Arteriovenous malformations
- Brachial plexus injury
- Brain injury
- Cerebral palsy
- Friedreich’s ataxia
- Guillain-Barré syndrome
- Lyme disease
- Multiple sclerosis
- Muscular dystrophy
- Neurofibromatosis
- Post-polio syndrome (PPS)
- Spina bifida
- Spinal cord injury
- Spinal muscular atrophy
- Spinal tumors
- Stroke (Cerebral Vascular Accident (CVA) and Spinal Stroke)
- Syringomyelia and tethered cord
- Transverse myelitis